Induction of DNA-damage and a tumor-inhibiting favorable SASP selectively in MYCN-amplified cells in vitro.Tumor regression and prolonged survival, with no evident toxicity in vivo.Significant reduction of MYCN mRNA and protein expression both in vitro and in vivoDecreased VEGF-A expression and tumor vascularization in vivo. This evidence concerns the gene MYCN and neoplasm.