mCTX induced greater tumor inhibition in MYCN-amplified xenografts, diminution of blood vessel density, and intratumoral bleeding, decreased Bcl-2 expression, and increased caspase-3 cleavage.Combining mCTX with calorie restricted KD resulted in tumor regression and complete growth arrest of both NB xenografts.Combining mCTX with optimized KD resulted in significant tumor growth suppression and prolonged survival, especially in SH-SY5Y xenografts, and inhibition of angiogenesis. Here, MYCN is linked to neoplasm.