HDAC1 has been shown to modulate the expression of several genes including Pax5, IKAROS family zinc finger 3 (IKZF3), members of the B-Cell receptor (BCR) pathway, immune regulators such as C-X-C motif chemokine receptor 4 (CXCR4), interleukin-16 (IL-16), interleukin-4 receptor (IL-4R), and Bcl-2 in CLL [107]. This evidence concerns the gene CXCR4 and B-cell chronic lymphocytic leukemia.