In MM, BRD4 interacts with super-enhancers that are related to pivotal MM genes, including cyclin D2 (CCDN2), PR/SET domain 1 (PRDM1), X-Box binding protein 1 (XBP1), or myeloid cell leukemia sequence 1 (BCL2-Related) (MCL1) [74], and recruits lysine methyltransferases and arginine demethylases (Figure 2) [92]. The gene discussed is PRDM1; the disease is Miyoshi myopathy.