CARM1 and plasma cell myeloma: Similarly, the coactivator-associated arginine methyltransferase 1/protein arginine N-methyltransferase-4 (CARM1/PRMT4), which induces histone 3 arginine 17 asymmetrical dimethylation (H3R17me2a) and histone 3 arginine 26 asymmetrical dimethylation (H3R26me2a), leading to transcriptional activation, has been enhanced in multiple myeloma.