PRMT5 and mantle cell lymphoma: The arginine methyltransferase PRMT5, which regulates important genes involved in proliferation, DNA damage response, and apoptosis such as p5, p21, growth arrest and DNA damage inducible alpha (GADD45), and P53-upregulated modulator of apoptosis (PUMA) [40], has also been highly overexpressed in B-cell- non-Hodgkin lymphoma (B-NHL) subtypes, such as DLBCL and MCL [41].