Particularly, MDS1 and EVI1 complex locus (MECOM), PBX homeobox 1 (PBX1), phosphatase and tensin homolog (Pten), and PR domain-containing 16 (PRDM16) methyltransferase gene rearrangements have been reported in some AML and MDS cases [43,44]. The gene discussed is RUNX1; the disease is acute myeloid leukemia.