KDM1A and acute lymphoblastic leukemia: In addition, lysine demethylase 1A (KDM1A/LSD1), which interacts with multiple protein complexes and may simultaneously act as a transcriptional activator and repressor in normal cells, is highly expressed in hematopoietic neoplasms, including ALL, AML, CML, MPNs, and MDSs [56,57].