HIPK2 and ischemic stroke: However, the binding sites between FBXO3 and HIPK2 in ischemic stroke have not been clarified within the present study, the exact mechanism of FBXO3 on inflammation through ubiquitinating and degrading HIPK2 deserves further attention, and whether there are other crosstalk pathways of FBXO3 involved in inflammation will be the focus of our future research.