WWOX and Alzheimer disease: For example, the WW domain-containing oxidoreductase (WWOX) gene, a high-density-lipoprotein cholesterol and triglyceride–associated gene which binds tau and has been involved in the regulation of tau hyperphosphorylation, neurofibrillary tangle formation and Aβ aggregation, was found to be mainly expressed in astrocytes and neurons from the brains of individuals with AD [83].