In fact, single-nuclei RNA-sequencing transcriptomics in post-mortem human brains with AD identified risk loci associated with astrocytic-mediated tauopathy, such as the genes for clustering (CLU), myocyte enhancer factor 2C (MEF2C) and IQ domain-containing protein K (IQCK) (a calcium binding protein whose function remains unclear) [74]. Here, MEF2C is linked to Alzheimer disease.