Susceptibility of asbestos-induced LC seems to be limited to dysregulation of ECM dynamics (and possibly to that of FGF19-FGFR4-induced EMT) while susceptibility to MPM seems more cancer-specific, retracing various aspects that have long been considered as key factors of asbestos-induced carcinogenesis: oxidative stress (with the novelty of heme involvement), chromosomal aberration due to nuclear–asbestos interaction, and EMT that both probably reflect the peculiarity of mesothelial cell cytoskeleton. Here, FGFR4 is linked to laryngotracheoesophageal cleft.