RUNX2 and lung adenocarcinoma: Interestingly, among the other defective pathways in the MPM group, one (R-HSA-8941326) affects RUNX2, the master gene in osteogenesis, which has been shown to increase expression of EMT genes (included in R-HSA-8941326) vimentin, TWIST1 and SNAIL1 in lung adenocarcinoma cells [59].