MMP14 and pleural mesothelioma: A potential gene–environment interaction between MMP SNPs and asbestos, which is the major risk factor for MMP, has been previously shown, with certain genetic variants in MMP genes exerting either protective or tumor-promoting effects on mesothelioma development [64]: (i) an Italian-based GWAS study found that MMP14, among other genes, could be a risk factor for MPM [25] and (ii) MMP2 rs243865 polymorphism has been described as protective for pleural mesothelioma development [65].