LMNA and familial dilated cardiomyopathy: We modeled the wild-type 690Arg and the 690Cys LAP2α proteins, and their interactions with lamin AC to provide further evidence of its possible functional effects and used confocal microscopy to compare morphological parameters of leukocyte nuclei from family members with different LMNA and TMPO genotype combinations to explore whether this variant can be considered a genetic modifier of DCM in patients with LMNA mutations.