KCNA1 and episodic ataxia type 1: Among the Kv1 and Kv2 α and Kvβ subunits known to be associated with AIS, only the KCNA1 gene encoding the Kv1.1 α subunit has mutant alleles associated with neurological disorders, in particular episodic ataxia type 1 (EA-1), often associated with seizures, which result from loss of function of Kv1.1-.containing channels [82,91,92,93].