E2F1 and cancer: Moreover, the involvement of several interactomes (HOTTIP/miR-124-3p/HMGA2; NEAT1/miR-124/p65; MALAT1/miR-124/CDK4; MALAT1/miR-124/TGF-β1; MALAT1/miR-124/HBx; UCA1/miR-124/JAG1; PTPRG-AS1/miR-124-3/LHX2; OIP5-AS1/miR-124-5p/IDH2) into several signaling pathways, such as Wnt/b-catenin pathway, E2F1 signaling, TGF-β signaling, SMAD pathway, ERK/MAPK pathway, HIF-1α-pathway, Notch signaling, PI3K/Akt signaling, and cancer cell stemness has been established [60,74,78,80,82,87,89,93].