SMAD5 and cancer: A report on the oncogenic role of lncRNA SNHG16 (small nucleolar RNA host 16) in various cancer types and its involvement in many signaling pathways, such as TGF-β1/SMAD5, mTOR, NF-kB, Wnt, RAS/RAF/MEK/ERK, and PI3K/AKT, was published [92].