The promoting effect of axes HOXA11-AS/miR-124/EZH2 (enhancer of zeste homolog 2 of polycomb group protein), HOXA11-AS/miR-124-3p/ITGB3 (integrin β3), and HOXA11-AS/miR-124/Sp1 (Sp1 transcriptional factor) on cancer cell proliferation, migration, invasion was shown in vitro. The gene discussed is EZH2; the disease is cancer.