This lncRNA is involved in two axes: PTPRG-AS1/miR-124-3p/CCND1 in lung adenocarcinoma and PTPRG-AS1/miR-124-3/LHX2 in nasopharyngeal carcinoma, which promote cell proliferation, cell cycle in vitro/in vivo, moreover, activation of LHX2 (LIM Homeobox 2) induces Notch pathway and reduces radiosensitivity [56,89]. The gene discussed is PTPRG; the disease is lung adenocarcinoma.