Additionally, in HBV-HCC tumors, some genes that are associated with macrophage/monocyte activation pathways were found to be upregulated, such as S100A11, MIF, S100A10, as well as S100A4, while some other genes were also upregulated, including TALDO1, MIF, S100A11, NOS1, and S100A6, that are involved in natural immunity [27,28]. The gene discussed is MIF; the disease is hepatocellular carcinoma.