The most important risk factors in defining a poor prognosis in early BC were high histological grade, histological type, i.e., pure tubular, pure mucinous, and pure cribriform histologies are at lower risk, N+ disease, tumor size T2 or greater, high level of Ki67 expression, low ER/PgR expression, residual cancer burden after neoadjuvant treatment and high-risk class at the genomic signature. This evidence concerns the gene PGR and breast cancer.