The level of both metalloproteinases was significantly higher in patients with a DM2 history longer than 10 years (MMP-3 = 125.7 pg/mL; MMP-9 = 2307.5 pg/mL) and in diabetic patients with obesity (MMP-3 = 128.6 pg/mL; MMP-9 = 2160.9 pg/mL). The gene discussed is MMP3; the disease is obesity due to melanocortin 4 receptor deficiency.