PSMD1 and COVID-19: Indeed, it has been suggested by other authors that the SARS-CoV-2 spike S1 protein directly interacts with and binds to the TAU protein, forming an S1–TAU complex or S1–Heparin–TAU complex, which presents stronger binding, increased neurological distress, and neurodegeneration, leading to severe COVID-19 and death [4,47].