Hu et al. revealed that hypoxia upregulated the expression of lncHILAR (LOC100506178) in human renal cell carcinoma (RCC) cell lines (Caki-1 and ACHN), which further promoted the invasion and metastasis of RCC cells through the mir-613/206/1-1-3p/jagged-1/notch/CXCR4 ceRNA axis [52]. This evidence concerns the gene CXCR4 and hereditary clear cell renal cell carcinoma.