Among the eight mRNAs in the model, the up-expressions of TKTL1, KDELR3, PFKP, SLC2A1, and PGF in hepatocellular carcinoma were confirmed in previous experimental studies, while the over-expression of SAP30 in HCC was reported in an earlier computational study. The gene discussed is KDELR3; the disease is hepatocellular carcinoma.