CD274 and cancer: We found that the hypoxia-related mRNAs, especially ENO2, in the ceRNA network were positively associated with PD1, PD-L1, or CTLA-4 in HCC, indicating that upregulating these mRNAs could promote the immune escape of cancer cells in hepatocytes, and targeting them could increase the efficacy of immunotherapy of patients with hepatocellular carcinoma.