Through RNA correlation analysis, we identified three lncRNA/miRNA/mRNA regulatory axes (SNHG1/hsa-miR-101-3p/SAP30, SNHG1/hsa-miR-101-3p/PPFIA4, SNHG1/hsa-miR-101-3p/TKTL1) that might be involved in the HCC development under the hypoxia environment. The gene discussed is PPFIA4; the disease is hepatocellular carcinoma.