Apart from TGM4, the urine levels of other proteins such as the von Willebrand factor (vWF), matrix metalloproteinase-2 (MMP2), metalloproteinase inhibitor 1 (TIMP1), pappalysin-2 (PAPPA2), and kallikrein-11 (KLK11) were found remarkably higher in CAD/AVS (>2.5-fold). This evidence concerns the gene PAPPA2 and coronary artery disorder.