CD4 and neoplasm: In the process of tumor immune escape, Tregs have been shown to suppress antigen presentation by myeloid-derived suppressor cells [590], DCs, CD4+ T helper (Th) cells and generate tumor-specific CD8+ cytotoxic T lymphocytes through TGF-β, IL-10, and IL-35 secretion (epstein-barr virus induced 3-IL-12α heterodimer) [586,591].