AKT1 and non-small cell lung carcinoma: It has been demonstrated that inhibition of Poly (ADP-ribose) polymerase-1 (PARP-1), a well-known active candidate in DNA repair, separately diminishes proliferation, migration, EMT, phosphorylation of EGFR, Akt, p38, NF-kB, and ERK in treated NSCLC with 12C [373,374].