The transgenic mice developed a human CML-like disease upon the induction of BCR-ABLp210 expression (tet withdrawal), and the disease was transplantable by the use of bone marrow cells that lacked lineage markers (lin-) and that expressed the Sca-1 antigen and the c-kit receptor (c-kit+) for stem cell factor (termed LSK), which is a classical signature for HSCs. Here, BCR is linked to chronic myelogenous leukemia, BCR-ABL1 positive.