Mounting evidence suggests that trauma-induced complement activation may provoke endotheliopathy that leads to SIRS, vascular hyperpermeability, MOF, and thrombotic thrombocytopenic purpura via the “two-path unifying theory”: (1) C5b-9-endotheliopathy-cytokine storm and (2) C5b-9-endotheliopathy-platelet activation/endothelial exocytosis of uncommonly massive von Willebrand factor [54,55]. This evidence concerns the gene VWF and systemic inflammatory response syndrome.