TRPC6 and amyloidosis: We demonstrate that C20 binds to the extracellular agonist binding site of the human TRPC6, protects hippocampal mushroom spines from amyloid toxicity in vitro, efficiently recovers synaptic plasticity in brain slices from aged 5xFAD mice, penetrates the blood–brain barrier (BBB) and recovers cognitive deficits in 5xFAD mice.