There were differences in the adiponectin protein expression in hepatocytes between Leprdb mice (T2DM group) and Dock7m mice (control group) when compared among different disease courses (4, 16, and 32 w) (Figure 1) (liver 4 w, p = 0.022; liver 16 w, p = 0.028; liver 32 w, p = 0.023). This evidence concerns the gene ADIPOQ and type 2 diabetes mellitus.