Perhaps a pivot of the effect of antidepressants on major depression through several previously mentioned signaling pathways, cAMP/PKA, phosphodiesterase, and neurotrophins, materializes through the activation of nuclear receptors, the glucocorticoid receptor (GR) and the mineralocorticoid (MR) [130,131,132,133,134]. This evidence concerns the gene NR3C2 and major depressive disorder.