That same pathway is also activated by the neuronal pentraxin 2 [121], encoded by the Nptx2 gene that is upregulated by FLX (Table 3, Table 9, Tables S5, S8 and S12) as already demonstrated in a previous study focused on a shared mechanism of AD effect of chronic FLX and exercise [118]. This evidence concerns the gene NPTX2 and Alzheimer disease.