In line with the neurotrophic hypothesis of depression, genes coding for members of the neurotrophic tyrosine receptor kinase family such as Ntrk2 and Ntrk3 were normalized by FLX action (Table 4, Table 6, Table 9 and Table S12) in a reverse direction compared to observation in rodent stress models of depression [115]. This evidence concerns the gene NTRK3 and major depressive disorder.