BDNF and depressive disorder: Other expected targets for FLX include brain-derived neurotrophic factor (BDNF), which is widely implicated in depression and the mechanisms of its treatment and would be expected to be increased [28], which is confirmed both in a stress paradigm (Table 4 and Table S5), or in naive animals (Table S8) and thus also in the overall meta-analysis (Table 9 and Table S12).