Using an antibody against the highly conserved extracellular amino acid residues of the AMPAR subunits GluA1-4 and the highly sensitive SDS-FRL method, with nearly one gold particle-one functional channel sensitivity [52], we were able to unravel the nanoscale organization of AMPARs in various synaptic connections in the CA1 field in physiological conditions and in tauopathy. The gene discussed is GRIA1; the disease is tauopathy.