The meta-analysis indicated that elevated Lp(a) was independently associated with an increased risk of cardiac events (cardiac death and acute coronary syndrome (ACS)) (relative risk (RR): 1.78; 95% CI: 1.31–2.42) and CV events (death, stroke, ACS, or coronary revascularization) (RR: 1.29; 95% CI: 1.17–1.42) in CHD patients. The gene discussed is LPA; the disease is stroke disorder.