In a meta-analysis of prospective studies with at least 1 year of follow-up published before 2000, a comparison of individuals in the top third of baseline plasma Lp(a) measurements with those in the bottom third in each study yielded a combined risk ratio of 1.6 (95% CI: 1.4–1.8; p < 0.00001), demonstrating a clear association between Lp(a) and IHD [32]. Here, LPA is linked to myocardial ischemia.