Among the 123 stable CHD patients, multiple logistic regression analysis revealed that Sd-LDL-C levels were significantly associated with clinically severe cases requiring coronary revascularization independently of LDL-C, HDL-C, and apo B. Both male and female CHD patients had significantly higher Sd-LDL-C concentrations than the control subjects [109]. This evidence concerns the gene APOB and coronary artery disorder.