Head and neck squamous cell carcinomas are complex diseases that demonstrate a remarkable multiplicity of genetic or epigenetic events [12,13], many of which converge into ErbB signaling circuitries [14].Simultaneous overexpression of multiple ErbB receptors in most head and neck squamous cell carcinoma cases suggests recurrent involvement of receptor heterodimers [15].The identification of the molecular importance of ErbBs in head and neck squamous cell carcinomas prompted evaluation of their potential as therapeutic targets [12,16,17]. This evidence concerns the gene EGFR and head and neck squamous cell carcinoma.