Previous reports have linked the TEAD1, HECW1, SEMA6A, COL13A1 and LAMA2 genes with different age-related cancers [15,16,17,18,19,20,21], the PLAT and ACE genes with cardiovascular disease [22,23,24,25], the ACE and HECW1 genes with Alzheimer’s disease [25,26] and the SEMA6A gene with type 2 diabetes [27]. Here, ACE is linked to early-onset autosomal dominant Alzheimer disease.