TGFB1 and osteoarthritis: The most prevalent causes of stenosis were ossification of the posterior longitudinal ligament associated with mutations in the TGF-β1 gene when replacing the rs1800470 SNP (G > A, C) allele, ossification of the ligamentum flavum associated with mutations leading to hypersecretion of TGF-β, and a point activating mutation in the TGFβ-1 gene inducing the formation of osteoarthritis of the facet joints.