KLF2 and endothelial dysfunction: In addition, as statins are studied well and proven to attenuate endothelial dysfunction via KLF2 activation [4,27], we then performed KLF2 promoter luciferase assays in COS-7 cells and TNFα-induced monocyte adhesion assays to compare the effects of statins (Simvastatin and Atorvastatin) with TSD.