This study’s limitations include its small sample size; the absence of a BDNF and/or CREB inhibition study; the effects of minocycline and memantine on naive animals; and the failure to assess beta-secretase (BACE) and C99 inflammatory protein levels, which could shed light on the relationship between neuroinflammation and amyloidosis. This evidence concerns the gene BACE1 and amyloidosis.