ELN and cardiac hypertrophy: The sex-dependent effect of SEP on heart weight is consistent with previous results, showing that (i) cardiac hypertrophy is favored by the male hormone testosterone and inhibited by the female hormone estrogens [39] and that (ii) the injected elastin peptide binding to the ERC improves the heart rate–blood pressure product (= heart work) in male rats, in a NO-dependent manner (proven post-ischemia) [40], which correlates with the left ventricle mass [41].