These elements are of importance in view of the possible future treatments of SVAS/WBS patients (and possibly cutis laxa patients), a high proportion of whom present cardiovascular abnormalities similar to those observed in Eln+/- mice, such as hypertension, altered arterial elastic lamellae/fibers, cardiac hypertrophy or increased arterial stiffness. The gene discussed is ELN; the disease is cardiac hypertrophy.