Group 5 (congenital cataracts) also shows abundant proteins involved in protein metabolism, among which three proteins—corticosteroid-binding globulin-SERPINA6, apolipoprotein A-IV (APOA4), and inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4)—were downregulated compared to other groups. The gene discussed is SERPINA6; the disease is Developmental cataract.