Among them, several hundred variants (including missense, frameshift, splicing site, nonsense and small deletion mutations) are shown to be associated with a wide range of HL phenotypes (the Deafness Variation Database: https://deafnessvariationdatabase.org/gene/SLC26A4, accessed on 6 June 2022; Clin-Var: https://www.ncbi.nlm.nih.gov/clinvar/?term=SLC26A4, accessed on 6 June 2022; the Human Gene Mutation Database: http://www.hgmd.cf.ac.uk/ac/, accessed on 1 February 2022). The gene discussed is SLC26A4; the disease is Hodgkins lymphoma.