Furthermore, the weight loss resulted from the practice of physical exercises, which can increase plasma adiponectin levels both in rodents and humans, as adiponectin released by physical practice can provoke stimulation in the oxidation of fatty acid and glucose uptake through the AMPK pathway, which is highly compromised in sarcopenic obesity patients [138]. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.