In 2004 [27], the transformation of monomeric cystatin C in amyloid fibrils at a very low pH of 2.0 was reported, but no molecular intermediates of this transformation were observed, while the SAXS and DLS results presented in this paper clearly indicate the presence at pH 2.2 of tetrameric HCC (without incubation). This evidence concerns the gene CST3 and hepatocellular carcinoma.