Among the down-regulated genes, solute carrier family 26 member 2 (SLC26A2) produces the circRNA has_circ_0074494, which is down-regulated in CRC cancer cell lines compared with that in normal colon epithelial cell lines, and actin gamma 2 smooth muscle (ACTG2) produces hsa_circ_0055267 and hsa_circ_0055266 that inhibit cell growth and reduce cell viability of small intestinal neuroendocrine tumor cells [23]. The gene discussed is ACTG2; the disease is colorectal carcinoma.