Different from pro-inflammatory cytokines such as TNF-α and IFN-γ, IL-10 is usually produced by Th2 cells, monocytes, macrophages and its leading role is to inhibit inflammation and Th1-dependent immune responses. Plays a hindering role in abortion caused by bacteria and facilitates Brucella escape from phagolysosome fusion [105]. This evidence concerns the gene TNF and abortion.