Different from pro-inflammatory cytokines such as TNF-α and IFN-γ, IL-10 is usually produced by Th2 cells, monocytes, macrophages and its leading role is to inhibit inflammation and Th1-dependent immune responses. Plays a hindering role in abortion caused by bacteria and facilitates Brucella escape from phagolysosome fusion [105]. The gene discussed is IL10; the disease is abortion.