Moreover, SLU7 downregulation also induces stress-response genes such as activating transcription factor 3 (Atf3) or Tp53, increases hepatocellular proliferation and induces a metabolic switch to a tumor-like glycolytic phenotype, triggering the expression of hexokinase 2 (Hk2) and pyruvate kinase m2 (Pkm2) and reducing the corresponding isoforms glucokinase (Gck) and L-pyruvate kinase (Lpk) [15]. This evidence concerns the gene ATF3 and neoplasm.