SLU7 and cancer: In fact, SLU7 knockdown could recapitulate many events that have been proposed separately as anti-cancer strategies, including global DNA demethylation [123,124], induction of R-loop formation [101,102,125,126], DNA damage [101,102], cell cycle arrest [127,128], mitotic stress [101,102], autophagy [129,130] and apoptosis [131,132].