Moreover, PET-derived radiomic features provided the best accuracy in the grading determination (AUC = 0.71), while both PET and MRI-derived features could predict hormone receptor status (AUC = 0.87 and 0.88 for estrogen receptor (ER) and progesterone receptor (PR), respectively), tumoral proliferation index, expressed in Ki-67 (AUC = 0.997), and lymph nodes and distant metastatic disease (AUC = 0.81 and 0.99, respectively). Here, ESR1 is linked to metastatic neoplasm.