Further, the levels of VEGF and FGF-2 in circulating platelets is increased in mice bearing human-tumor xenografts compared with tumor-free controls [48], suggesting that tumors may affect the net proteomic content in platelets regulating how the proteins are redistributed and secreted and that platelet levels of angiogenesis-related proteins may be higher than plasma and serum levels. This evidence concerns the gene FGF2 and neoplasm.