LOXL2 and neoplasm: Recently, platelet growth factor receptor β (PDGFRβ) has been identified as a new class of LOXL2 substrate, where tumor cell–secreted LOXL2 together with platelet derived growth factor (PDGF)–AB have been shown to activate PDGFRβ in fibroblasts to promote cell proliferation via activation of the ERK signaling pathway [11].