In our previous work, we came to the conclusion that the dual role of huMETCAM/MUC18 in the progression of several human cancers is generally found in the different cell lines of the same cancer type or different cancer types, suggesting that huMETCAM/MUC18 affects the tumorigenesis and metastasis of epithelial tumor cell lines in a very complex way. This evidence concerns the gene MCAM and cancer.