The tumor suppression of huMETCAM/MUC18 on the NPC cells was not due to decreasing the in vitro (intrinsic) growth rate of the NPC-TW01 cells, but rather, it might be due to the inhibition of the intrinsic in vivo growth via elevated apoptosis and decreased anti-apoptosis, proliferation, survival pathway, and angiogenesis and the rewiring of the metabolic switch to aerobic glycolysis. Here, MCAM is linked to neoplasm.