ABCB4 and gallbladder disease 1: The mutation of the ABCB4 may lead to low-phospholipid associated cholelithiasis (LPAC) defined by the presence of symptomatic and recurrent cholelithiasis in young patients with abnormal ultrasound of the liver, progressive familial intrahepatic cholestasis (PFIC) type 3, low phospholipid-associated cholelithiasis, and intrahepatic cholestasis of pregnancy [25].