Although the injection of naked CAG-PMOs requires local administration and electroporation, their conjugation with an arginine-rich CPP (K-peptide) enables them to have a significant effect on MBNL1 release from foci and mis-splicing corrections in addition to correcting myotonia to near-normal levels following intravenous injections at 30 mg/kg in HSALR mice [98]. Here, MBNL1 is linked to Myotonia.