Since the successful construction of murine CRC organoids from a single LGR5+ crypt stem cell by the Hans Clevers team, organoid culture techniques have become increasingly mature [12], and specialized organoid culture conditions for adenoma, adenocarcinoma, Barrett’s esophagus, and other cancerous and precancerous epithelia have been explored [13,14,15]. The gene discussed is LGR5; the disease is colorectal carcinoma.