AKT1 and breast carcinoma: Given evidence that FAK is involved in integrin-dependent activation of PI3Ks [116,117] and that the AKT cascade can be activated by integrins and PI3K [118], these authors suggested that the integrin/FAK and PI3K/AKT pathways jointly contribute to the metastasis-inhibiting effect of furanodiene in breast cancer cases [73].