In a rat model of PTSD, four weeks of treadmill exercise protocol ameliorated stress-induced enhanced anxiety levels, serum CORT, the BDNF protein level in the hippocampus and serum, and apoptosis markers (Bax, Bcl-2, and Caspase 3) as compared to the sedentary rats [102]. The gene discussed is CORT; the disease is post-traumatic stress disorder.