C5 and early-onset autosomal dominant Alzheimer disease: In rodent models, PMX205 has shown beneficial effects in amyotrophic lateral sclerosis [72,73], striatal neurodegeneration [74], spinal cord injury [75,76], reduction of memory loss in mice with Alzheimer’s disease [77,78], and in Naja annulifera snake envenomation, demonstrating the importance of the C5a-C5aR1 axis in the immunopathology caused by this venom [79].