TP53 and posterior cortical atrophy: Furthermore, a significant association was observed between higher Gleason Groups when combining CDK2AP1 expression with other PCa biomarkers, (high CDK2AP1 expression/PTEN loss, high CDK2AP1/AR expression, high CDK2AP1/ERG positive, and high CDK2AP1/abnormal p53 expression (p < 0.0001, p < 0.0001, p < 0.0001, p < 0.0001, respectively) (Table 1).