PTEN and posterior cortical atrophy: When high CDK2AP1 expression was combined with other PCa molecular subtypes (Figure 2), PTEN-loss and high CDK2AP1 expression were even more significantly associated with poorer OS (HR: 2.83, CI: 1.89–4.24, p < 0.0001) and CSS (HR: 4.43, CI: 2.28–7.93, p < 0.0001) compared to each marker individually or any other combination of the two specifically in relation to CCS in univariate analysis (Table 2).