As reported in Table 1, observational studies show that the rs738409 C > G p.I148M variant in the patatin-like phospholipase domain-containing protein-3 (PNPLA3) gene and some other genetic polymorphisms related to a greater susceptibility to NAFLD and NASH may also play a role in the development and progression of kidney damage in both adults and adolescents [47,48,49,50,51,52,53,54,55,56,57]. Here, PNPLA3 is linked to metabolic dysfunction-associated steatohepatitis.