SLC5A2 and chronic kidney disease: Given that nondiabetic CKD also exhibits single-nephron hyperfiltration and elevated albuminuria, SGLT-2 inhibitors may currently be repositioned from diabetic to nondiabetic kidney disease, and large phase 3 RCTs are currently ongoing to examine the efficacy and safety of these agents in patients with CKD owing to both diabetic and nondiabetic etiologies [133,134].