For example, Targher et al. showed that, after adjustment for age, sex, blood pressure, adiposity measures, insulin resistance, and the histological severity of NAFLD, the presence of rs738409 C > G p.I148M in the PNPLA3 gene was associated with both lower eGFR levels and higher 24 h proteinuria in a cohort of 142 overweight children and adolescents [48]. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.