This research was carried out on an in vitro model, where nasopharyngeal carcinoma cells showed that SAHA activates tumor suppressors such as p53 and Rb1 (retinoblastoma protein), while, at the same time, inactivating AMPK (5′ AMP-activated protein kinase) signaling, which leads to apoptosis [84]. This evidence concerns the gene TP53 and neoplasm.