NPHS1 and Hypertension: Liao et al. reported that Ac-SDKP treatment greatly prevented and reversed albuminuria and renal fibrosis as well as improved renal function in 5/6 Nephrectomy (5/6Nx)-induced hypertensive rat model and these events were associated with a decrease in inflammation, glomerulosclerosis, and an increase in the glomerular slit pore protein, nephrin [78].