TGFB1 and silicosis: They further demonstrated that Ac-SDKP alleviated fibrosis through inhibiting the transition of epithelial cells to myofibroblasts mediated by activating the TGF-β1/ ROCK1 pathway in rat silicosis model and in cultured human embryo lung fibroblast MRC-5 and the human alveolar epithelial cell line A549 exposed to TGF-β1 [120].