Furthermore, Xu et al. showed that intrinsic Tβ4 was upregulated in early-stage glomerulosclerosis induced by 5/6 nephrectomy, and this was related to the expression of a profibrogenic factor, angiotensin II (Ang II)-induced PAI-1 in cultured glomerular endothelial cells. This evidence concerns the gene AGT and glomerulosclerosis.