Although the mechanism causing the disease susceptibility is not fully clear, ARMS2 A69S polymorphism influences the anti-VEGF response in late-stage AMD, notably in the East Asian population [48], suggesting that the latter mutation may serve as a prognostic factor for the anti-VEGF response, especially in A-allele carriers or the AA genotype, whose detection may be an indication for early intervention [49]. The gene discussed is VEGFA; the disease is age-related macular degeneration.