C5 and age-related macular degeneration: Intravitreal administration of Avacincaptad pegol, a pegylated RNA aptamer which is another C5 agent, also known as Zimura (IVERIC bio), proved to be safe and effective in reducing GA growth in AMD eyes in the GATHER1 study by preventing the formation of C5a and C5b independently to the starting point of the pathway (alternate, classic, or lectin) [157].