A clinical trial (NCT04439708) is now ongoing to disclose biomarkers in the blood and aqueous humor in a population of AMD with occult CNV and analyse their relationship with the response to anti-VEGF treatment; another one (NCT05038371) aims to measure levels of connective tissue growth factor (CTGF) in the aqueous humor of patients with neovascular AMD and compare them to controls. This evidence concerns the gene CCN2 and age-related macular degeneration.